Palladium-catalyzed coupling of alkyl chlorides and Grignard reagents

Anja C. Frisch, Nadim Shaikh, Alexander Zapf, Matthias Belier

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

Chloroalkanes refined: A simple catalyst system renders the palladium-catalyzed coupling reaction of functionalized alkyl chlorides and Grignard reagents at room temperature (see example in scheme; PCy3 = tricyclohexylphosphane, NMP = N-methylpyrrolidinone).

Original languageEnglish
Pages (from-to)4056-4059
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume41
Issue number21
DOIs
StatePublished - 4 Nov 2002
Externally publishedYes

Keywords

  • Alkyl halides
  • Cross-coupling
  • Grignard reaction
  • Kumada coupling
  • Palladium

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