Palladium-catalyzed carbonylative synthesis of quinazolinones from 2-aminobenzamide and aryl bromides

Xiao Feng Wu, Lin He, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

C from CO! A straightforward procedure for the carbonylative synthesis of quinazolinones from readily available 2-aminobenzamide and aryl bromides has been developed. In the presence of a palladium catalyst, various quinazolinones were produced in moderate to excellent yields. Remarkably, no chromatography was needed for purification (see scheme).

Original languageEnglish
Pages (from-to)12635-12638
Number of pages4
JournalChemistry - A European Journal
Volume19
Issue number38
DOIs
StatePublished - 16 Sep 2013
Externally publishedYes

Keywords

  • aryl bromides
  • carbonylation
  • cascade reactions
  • palladium
  • quinazolinones

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