Palladium-catalyzed carbonylative synthesis of N-(2-cyanoaryl)benzamides and sequential synthesis of quinazolinones

Xiao Feng Wu, Stefan Oschatz, Muhammad Sharif, Matthias Beller, Peter Langer

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

A convenient procedure for the synthesis of N-(2-cyanoaryl)benzamides has been developed. Using aryl bromides and 2-aminobenzonitriles as the substrates, Mo(CO)6 as the CO source, the desired amides were produced in good yields. Quinazolinones were produced in good yields in a sequential manner as well.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalTetrahedron
Volume70
Issue number1
DOIs
StatePublished - 7 Jan 2014
Externally publishedYes

Keywords

  • Amide
  • Carbonylation
  • Mo(CO)
  • Palladium catalyst
  • Quinazolinone

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