Palladium-catalyzed carbonylative coupling of benzyl chlorides with terminal alkynes to give 1,4-diaryl-3-butyn-2-ones and related furanones

Xiao Feng Wu, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

A general palladium-catalyzed carbonylative Sonogashira coupling of benzyl chlorides with terminal acetylenes has been established. Depending on the alkyne 1,4-diaryl-3-butyn-2-ones or substituted furanones are obtained in moderate to good yields. Best catalytic performance is achieved applying a mixed Pd(PPh 3)Cl 2/P(OPh) 3 catalyst system.

Original languageEnglish
Pages (from-to)8003-8005
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number23
DOIs
StatePublished - 7 Dec 2011
Externally publishedYes

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