Palladium-catalyzed carbonylative [3+2+1] annulation of N-aryl-pyridine-2-amines with internal alkynes by C-H activation: Facile synthesis of 2-quinolinones

Jianbin Chen, Kishore Natte, Anke Spannenberg, Helfried Neumann, Matthias Beller, Xiao Feng Wu

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64 Scopus citations

Abstract

We describe here a novel procedure for the synthesis of highly substituted 2-quinolinones. By this newly developed approach, 2-quinolinone derivatives were prepared in moderate to good yields by carbonylative cyclization of N-aryl-pyridine-2-amines and internal alkynes by C-H activation. Remarkably, [Mo(CO)6] was applied as a solid CO source and the reaction proceeded in an atom economic manner.

Original languageEnglish
Pages (from-to)14189-14193
Number of pages5
JournalChemistry - A European Journal
Volume20
Issue number44
DOIs
StatePublished - 27 Oct 2014
Externally publishedYes

Keywords

  • C-h activation
  • Carbonylation
  • Domino reactions
  • Palladium
  • Quinonlinone

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