Palladium-catalyzed carbonylation reactions of aryl halides and related compounds

Anne Brennführer, Helfried Neumann, Matthias Beller

Research output: Contribution to journalReview articlepeer-review

1262 Scopus citations


Palladium-catalyzed carbonylation reactions of aromatic halides in the presence of various nucleophiles have undergone rapid development since the pioneering work of Heck and co-workers in 1974, such that nowadays a plethora of palladium catalysts are available for different carbonylative transformations. The carboxylic acid derivatives, aldehydes, and ketones prepared in this way are important intermediates in the manufacture of dyes, pharmaceuticals, agro-chemicals, and other industrial products. In this Review, the recent academic developments in this area and the first industrial processes are summarized.

Original languageEnglish
Pages (from-to)4114-4133
Number of pages20
JournalAngewandte Chemie International Edition in English
Issue number23
StatePublished - 25 May 2009
Externally publishedYes


  • Aryl halides
  • Carbon monoxide
  • Carbonylation
  • Homogeneous catalysis
  • Palladium


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