Palladium-Catalyzed Carbonylation of sec- and tert-Alcohols

Kaiwu Dong, Rui Sang, Jie Liu, Rauf Razzaq, Robert Franke, Ralf Jackstell, Matthias Beller

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

A general palladium-catalyzed synthesis of linear esters directly from sec- and tert-alcohols is described. Compared to the classic Koch–Haaf reaction, which leads to branched products, this new transformation gives the corresponding linear esters in high yields and selectivity. Key for this protocol is the use of an advanced palladium catalyst system with L2 (pytbpx) as the ligand. A variety of aliphatic and benzylic alcohols can be directly used and the catalyst efficiency for the benchmark reaction is outstanding (turnover number up to 89 000).

Original languageEnglish
Pages (from-to)6203-6207
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume56
Issue number22
DOIs
StatePublished - 22 May 2017
Externally publishedYes

Keywords

  • alcohols
  • carbonylation
  • catalysis
  • esters
  • palladium

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