Palladium-Catalyzed Carbonylation of Allylic Chlorides to β,γ-Unsaturated Esters/Amides under Mild Conditions

Peng Wang, Zhusong Cao, Yaxin X. Wang, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Improved procedures for carbonylative transformations (alkoxy- and aminocarbonylation) of cinnamyl chloride to synthesize β,γ-unsaturated esters/amides have been developed. Studying critical reaction parameters (palladium precursors, solvents and bases) enabled the practical preparation of diverse β,γ-unsaturated esters/amides under mild conditions (low Pd catalyst loading, phosphine-free, 2 bar CO, 60 °C). The optimal catalytic system shows excellent chemo- and regioselectivity for the activation of the allylic C−Cl bonds.

Original languageEnglish
Article numbere202200663
JournalEuropean Journal of Organic Chemistry
Volume2022
Issue number30
DOIs
StatePublished - 12 Aug 2022
Externally publishedYes

Keywords

  • Alkoxycarbonylation
  • Allyl chlorides
  • Aminocarbonylation
  • Palladium

Fingerprint

Dive into the research topics of 'Palladium-Catalyzed Carbonylation of Allylic Chlorides to β,γ-Unsaturated Esters/Amides under Mild Conditions'. Together they form a unique fingerprint.

Cite this