Palladium-catalyzed carbonylation of 2-bromoanilines with 2-formylbenzoic acid and 2-halobenzaldehydes: Efficient synthesis of functionalized isoindolinones

Kishore Natte, Jianbin Chen, Haoquan Li, Helfried Neumann, Matthias Beller, Xiao Feng Wu

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

A concise and highly versatile method for the synthesis of functionalized isoindolinones is reported. Various 2-bromoanilines undergo palladium-catalyzed carbonylation with 2-formylbenzoic acid under a convenient and mild procedure to give good to excellent yields of the corresponding isoindolinones. Additionally, 2-halobenzaldehydes can be applied as substrates in palladium-catalyzed double-carbonylation to provide identical compounds in moderate to good yields.

Original languageEnglish
Pages (from-to)14184-14188
Number of pages5
JournalChemistry - A European Journal
Volume20
Issue number44
DOIs
StatePublished - 27 Oct 2014
Externally publishedYes

Keywords

  • Carbonylation
  • Cascade reactions
  • Heterocycles
  • Isoindolinones
  • Palladium

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