Palladium-catalyzed amination and sulfonylation of 5-bromo-3-[2- (diethylamino)ethoxy]indoles to potential 5-HT6 receptor ligands

Nicolle Schwarz, Anahit Pews-Davtyan, Dirk Michalik, Annegret Tillack, Karolin Krüger, Antoni Torrens, José Luis Diaz, Matthias Beller

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A general and efficient palladium-catalyzed amination of 5-bromo-3-[2-(diethylamino)ethoxy]indoles has been developed. Best results are obtained in the presence of Pd(OAc)2 and 2-[di(1-adamantyl) phosphanyl]-1-phenylpyrrole as ligand. Subsequent sulfonylation gave novel indole derivatives, which are of interest as potentially biological active 5-HT6 receptor ligands.

Original languageEnglish
Pages (from-to)5425-5435
Number of pages11
JournalEuropean Journal of Organic Chemistry
Issue number32
DOIs
StatePublished - Nov 2008
Externally publishedYes

Keywords

  • Amination
  • Indole
  • Palladium
  • Sulfonylation

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