Palladium catalyst systems for cross-coupling reactions of aryl chlorides and olefins

Alexander Zapf, Matthias Beller

Research output: Contribution to journalArticlepeer-review

145 Scopus citations


A detailed investigation into the influence of phosphines, additives, bases and solvents on the Heck coupling reaction of 4-trifluoromethyl-1-chlorobenzene (2) is presented. It is shown that a number of catalyst systems exist for efficient cross coupling of electron-deficient aryl chlorides with various olefins. Basicity and steric demand of the ligand are two factors which determine the success of the reaction. In addition the phosphine/palladium ratio, the correct type and amount of additive, and finally the use of an appropriate base and solvent are also important. The optimised reaction conditions are applied for the arylation of styrene, 2-ethylhexyl acrylate and N,N-dimethyl acrylic amide with various aryl chlorides.

Original languageEnglish
Pages (from-to)2908-2915
Number of pages8
JournalChemistry - A European Journal
Issue number13
StatePublished - 2 Jul 2001
Externally publishedYes


  • Additives
  • Arylation
  • C-Cl activation
  • Homogeneous catalysis
  • Palladium


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