Palladium-catalysed Suzuki-Miyaura coupling reactions of Bromhexine and Ambroxol

Muhammad Sharif, Anahit Pews-Davtyan, Jan Lukas, Susann Pohlers, Arndt Rolfs, Peter Langer, Matthias Beller

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The Suzuki-Miyaura coupling reaction was applied for the synthesis of biologically relevant derivatives of known mucolytic agents Bromhexine and Ambroxol. Using commercially available electron-rich and electron-poor arylboronic acids the desired products are obtained in moderate to high yields (42-81%).

Original languageEnglish
Pages (from-to)5128-5135
Number of pages8
JournalTetrahedron
Volume70
Issue number34
DOIs
StatePublished - 26 Aug 2014
Externally publishedYes

Keywords

  • Ambroxol
  • Bromhexine
  • Catalysis
  • Palladium
  • Suzuki-Miyaura

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