Palladium-catalysed regioselective hydroamination of 1,3-dienes: Synthesis of allylic amines

Debasis Banerjee, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Catalytic hydroamination of unactivated 1,3-dienes represents a sustainable and atom-economic C-N bond forming process. Here, we present a novel catalytic system consisting of Pd(cod)Cl2 in combination with DPEphos for the selective 1,4-hydroamination (anti-Markovnikov reaction) of a series of acyclic and cyclic dienes. The reactions proceed in good yields and allow for the exclusive formation of allylic amines with high regioselectivity and do not need any additives.

Original languageEnglish
Pages (from-to)368-372
Number of pages5
JournalOrganic Chemistry Frontiers
Volume1
Issue number4
DOIs
StatePublished - 1 Apr 2014
Externally publishedYes

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