Oxytocin Shapes Spontaneous Activity Patterns in the Developing Visual Cortex by Activating Somatostatin Interneurons

Paloma P. Maldonado; Alvaro Nuno-Perez; Jan H. Kirchner; Elizabeth Hammock; Julijana Gjorgjieva; Christian Lohmann

doi:10.1016/j.cub.2020.10.028

Oxytocin Shapes Spontaneous Activity Patterns in the Developing Visual Cortex by Activating Somatostatin Interneurons

Paloma P. Maldonado
, Alvaro Nuno-Perez
, Jan H. Kirchner
, Elizabeth Hammock
, Julijana Gjorgjieva
, Christian Lohmann

Associate Professorship of Computational Neuroscience

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Maldonado et al. uncover oxytocin's role in developing sensory cortices. In vivo, they show that oxytocin decreases the frequency and correlations of spontaneous activity patterns in V1 by specifically activating somatostatin⁺ interneurons. In S1, oxytocin increases both excitation and inhibition and does not affect spontaneous activity frequency.

Original language	English
Pages (from-to)	322-333.e5
Journal	Current Biology
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.cub.2020.10.028
State	Published - 25 Jan 2021

Keywords

calcium imaging
mouse
neuromodulator
neuronal excitability
patch-clamp
somatosensory cortex

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10.1016/j.cub.2020.10.028

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title = "Oxytocin Shapes Spontaneous Activity Patterns in the Developing Visual Cortex by Activating Somatostatin Interneurons",

abstract = "Maldonado et al. uncover oxytocin's role in developing sensory cortices. In vivo, they show that oxytocin decreases the frequency and correlations of spontaneous activity patterns in V1 by specifically activating somatostatin+ interneurons. In S1, oxytocin increases both excitation and inhibition and does not affect spontaneous activity frequency.",

keywords = "calcium imaging, mouse, neuromodulator, neuronal excitability, patch-clamp, somatosensory cortex",

author = "Maldonado, \{Paloma P.\} and Alvaro Nuno-Perez and Kirchner, \{Jan H.\} and Elizabeth Hammock and Julijana Gjorgjieva and Christian Lohmann",

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AU - Maldonado, Paloma P.

AU - Nuno-Perez, Alvaro

AU - Kirchner, Jan H.

AU - Hammock, Elizabeth

AU - Gjorgjieva, Julijana

AU - Lohmann, Christian

PY - 2021/1/25

Y1 - 2021/1/25

N2 - Maldonado et al. uncover oxytocin's role in developing sensory cortices. In vivo, they show that oxytocin decreases the frequency and correlations of spontaneous activity patterns in V1 by specifically activating somatostatin+ interneurons. In S1, oxytocin increases both excitation and inhibition and does not affect spontaneous activity frequency.

AB - Maldonado et al. uncover oxytocin's role in developing sensory cortices. In vivo, they show that oxytocin decreases the frequency and correlations of spontaneous activity patterns in V1 by specifically activating somatostatin+ interneurons. In S1, oxytocin increases both excitation and inhibition and does not affect spontaneous activity frequency.

KW - calcium imaging

KW - mouse

KW - neuromodulator

KW - neuronal excitability

KW - patch-clamp

KW - somatosensory cortex

UR - https://www.scopus.com/pages/publications/85096942473

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DO - 10.1016/j.cub.2020.10.028

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JO - Current Biology

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IS - 2

ER -

Oxytocin Shapes Spontaneous Activity Patterns in the Developing Visual Cortex by Activating Somatostatin Interneurons

Abstract

Keywords

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