Oxygen tensions in rodent tumors after irradiation with neutrons

L. Weissfloch, T. Auberger, R. Senekowitsch-Schmidtke, F. M. Wagner, K. Tempel, M. Molls

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We started investigations on intratumoral oxygen tension after irradiations with reactor fission neutrons using the Eppendorf-pO2 Histograph(R). Isotransplanted AT17-mammary carcinomas on C3H-mice and osteosarcomas OTS-64 on balb C-mice received 2 or 6 Gy neutrons single dose. Before and at certain points of time after treatment the pO2 values were evaluated. Some tumors with initially low median pO2 values showed a short- lasting increase between 2 and 24 h after irradiation. In those tumors with relatively high pretherapeutic pO2 values the pO2 decreased to the range of hypoxia. A third group of tumors showed no marked changes after irradiation. No tumor stopped growth during the observation period.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalAdvances in Experimental Medicine and Biology
Volume411
DOIs
StatePublished - 1997
Externally publishedYes

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