Oxidativer stress bei hämodialysepatienten - Auslösende faktoren und mögliche behandlung

Translated title of the contribution: Oxidative stress in hemodialysis patients - Causing factors and potential strategies of treatment

N. Bader, L. Renders, Manfred James Müller

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic hemodialysis patients have an increased cardiovascular morbidity and mortality. The cardiovascular complications can only be in part explained by uremia caused cardiovascular risk factors like dys- and hyperlipidemia, hypertension, hyperhomocysteinemia, hyperphosphatemia and hypoalbuminemia. Oxidative stress, malnutrition and inflammation seem to be major determinants of cardiovascular morbidity and mortality. Chronic hemodialysis patients have oxidative stress as a result of the primary disease, dialysis itself as well as of altered metabolism. Oxidative stress is accompanied by lower serum levels of antioxidants. As a consequence there is an imbalance between oxidative and antioxidative factors (oxidative > antioxidative). Oxidative modifications on macromolecules like lipids, proteins and the DNA can be assessed by different biomarkers. Supplementation of antioxidants (tocopherols) and the use of biocompatible and vitamin E coated dialysis membrans can decrease oxidative modifications.

Translated title of the contributionOxidative stress in hemodialysis patients - Causing factors and potential strategies of treatment
Original languageGerman
Pages (from-to)254-258
Number of pages5
JournalAktuelle Ernahrungsmedizin
Volume29
Issue number5
DOIs
StatePublished - Oct 2004
Externally publishedYes

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