Oxidative synthesis of quinazolinones and benzothiadiazine 1,1-dioxides from 2-aminobenzamide and 2-aminobenzenesulfonamide with benzyl alcohols and aldehydes

Muhammad Sharif, Julita Opalach, Peter Langer, Matthias Beller, Xiao Feng Wu

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108 Scopus citations

Abstract

An interesting procedure for the zinc-catalyzed oxidative transformation of ready available 2-aminobenzamide, 2-aminobenzenesulfonamide with benzyl alcohols has been developed. Various quinazolinones and benzothiadiazine 1,1-dioxides were prepared in moderate to good yields under identical conditions. The reactions of both aromatic aldehydes and aliphatic aldehydes with 2-aminobenzamide under catalyst free conditions were described as well. In water media, the products were formed in good yields.

Original languageEnglish
Pages (from-to)8-17
Number of pages10
JournalRSC Advances
Volume4
Issue number1
DOIs
StatePublished - 2014
Externally publishedYes

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