Overexpression of a member of the pentraxin family (PTX3) in human soft tissue liposarcoma

F. Willeke; A. Assad; P. Findeisen; E. Schromm; R. Grobholz; B. von Gerstenbergk; A. Mantovani; S. Peri; H. H. Friess; S. Post; M. von Knebel Doeberitz; M. H.M. Schwarzbach

doi:10.1016/j.ejca.2006.05.035

Overexpression of a member of the pentraxin family (PTX3) in human soft tissue liposarcoma

F. Willeke, A. Assad, P. Findeisen, E. Schromm, R. Grobholz, B. von Gerstenbergk, A. Mantovani, S. Peri, H. H. Friess, S. Post, M. von Knebel Doeberitz, M. H.M. Schwarzbach

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

A unique feature of human soft tissue liposarcoma is a stable (12;16)(q13;p11) translocation observed mainly in myxoid and roundcell liposarcomas. This translocation results in FUS/CHOP fusion transcripts with a corresponding oncogenic protein. We hypothesised that genes downstream of FUS/CHOP might serve as attractive candidates for novel tumour associated antigens. Among a panel of analysed genes, only pentraxin related gene (PTX3) demonstrated high expression in liposarcomas as compared to normal tissues. The analysis of RNA and protein expression demonstrated concordant results. However, the level of RNA and protein overexpression did not correlate in all cases. Finally, PTX3 expression was not related to presence of a FUS/CHOP fusion transcript within the liposarcoma tissues. PTX3 has been associated with adipocyte differentiation and now, additionally, is characterised by a markedly increased expression in human soft tissue liposarcoma. This finding mandates further research efforts to clarify the exact role of PTX3 in liposarcoma oncogenesis.

Original language	English
Pages (from-to)	2639-2646
Number of pages	8
Journal	European Journal of Cancer
Volume	42
Issue number	15
DOIs	https://doi.org/10.1016/j.ejca.2006.05.035
State	Published - Oct 2006
Externally published	Yes

Keywords

FUS/CHOP
Fusion transcript
Liposarcoma
Pentraxin
PTX3

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejca.2006.05.035

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Willeke, F., Assad, A., Findeisen, P., Schromm, E., Grobholz, R., von Gerstenbergk, B., Mantovani, A., Peri, S., Friess, H. H., Post, S., von Knebel Doeberitz, M., & Schwarzbach, M. H. M. (2006). Overexpression of a member of the pentraxin family (PTX3) in human soft tissue liposarcoma. European Journal of Cancer, 42(15), 2639-2646. https://doi.org/10.1016/j.ejca.2006.05.035

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title = "Overexpression of a member of the pentraxin family (PTX3) in human soft tissue liposarcoma",

abstract = "A unique feature of human soft tissue liposarcoma is a stable (12;16)(q13;p11) translocation observed mainly in myxoid and roundcell liposarcomas. This translocation results in FUS/CHOP fusion transcripts with a corresponding oncogenic protein. We hypothesised that genes downstream of FUS/CHOP might serve as attractive candidates for novel tumour associated antigens. Among a panel of analysed genes, only pentraxin related gene (PTX3) demonstrated high expression in liposarcomas as compared to normal tissues. The analysis of RNA and protein expression demonstrated concordant results. However, the level of RNA and protein overexpression did not correlate in all cases. Finally, PTX3 expression was not related to presence of a FUS/CHOP fusion transcript within the liposarcoma tissues. PTX3 has been associated with adipocyte differentiation and now, additionally, is characterised by a markedly increased expression in human soft tissue liposarcoma. This finding mandates further research efforts to clarify the exact role of PTX3 in liposarcoma oncogenesis.",

keywords = "FUS/CHOP, Fusion transcript, Liposarcoma, Pentraxin, PTX3",

author = "F. Willeke and A. Assad and P. Findeisen and E. Schromm and R. Grobholz and {von Gerstenbergk}, B. and A. Mantovani and S. Peri and Friess, {H. H.} and S. Post and {von Knebel Doeberitz}, M. and Schwarzbach, {M. H.M.}",

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Willeke, F, Assad, A, Findeisen, P, Schromm, E, Grobholz, R, von Gerstenbergk, B, Mantovani, A, Peri, S, Friess, HH, Post, S, von Knebel Doeberitz, M & Schwarzbach, MHM 2006, 'Overexpression of a member of the pentraxin family (PTX3) in human soft tissue liposarcoma', European Journal of Cancer, vol. 42, no. 15, pp. 2639-2646. https://doi.org/10.1016/j.ejca.2006.05.035

TY - JOUR

T1 - Overexpression of a member of the pentraxin family (PTX3) in human soft tissue liposarcoma

AU - Willeke, F.

AU - Assad, A.

AU - Findeisen, P.

AU - Schromm, E.

AU - Grobholz, R.

AU - von Gerstenbergk, B.

AU - Mantovani, A.

AU - Peri, S.

AU - Friess, H. H.

AU - Post, S.

AU - von Knebel Doeberitz, M.

AU - Schwarzbach, M. H.M.

PY - 2006/10

Y1 - 2006/10

N2 - A unique feature of human soft tissue liposarcoma is a stable (12;16)(q13;p11) translocation observed mainly in myxoid and roundcell liposarcomas. This translocation results in FUS/CHOP fusion transcripts with a corresponding oncogenic protein. We hypothesised that genes downstream of FUS/CHOP might serve as attractive candidates for novel tumour associated antigens. Among a panel of analysed genes, only pentraxin related gene (PTX3) demonstrated high expression in liposarcomas as compared to normal tissues. The analysis of RNA and protein expression demonstrated concordant results. However, the level of RNA and protein overexpression did not correlate in all cases. Finally, PTX3 expression was not related to presence of a FUS/CHOP fusion transcript within the liposarcoma tissues. PTX3 has been associated with adipocyte differentiation and now, additionally, is characterised by a markedly increased expression in human soft tissue liposarcoma. This finding mandates further research efforts to clarify the exact role of PTX3 in liposarcoma oncogenesis.

AB - A unique feature of human soft tissue liposarcoma is a stable (12;16)(q13;p11) translocation observed mainly in myxoid and roundcell liposarcomas. This translocation results in FUS/CHOP fusion transcripts with a corresponding oncogenic protein. We hypothesised that genes downstream of FUS/CHOP might serve as attractive candidates for novel tumour associated antigens. Among a panel of analysed genes, only pentraxin related gene (PTX3) demonstrated high expression in liposarcomas as compared to normal tissues. The analysis of RNA and protein expression demonstrated concordant results. However, the level of RNA and protein overexpression did not correlate in all cases. Finally, PTX3 expression was not related to presence of a FUS/CHOP fusion transcript within the liposarcoma tissues. PTX3 has been associated with adipocyte differentiation and now, additionally, is characterised by a markedly increased expression in human soft tissue liposarcoma. This finding mandates further research efforts to clarify the exact role of PTX3 in liposarcoma oncogenesis.

KW - FUS/CHOP

KW - Fusion transcript

KW - Liposarcoma

KW - Pentraxin

KW - PTX3

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VL - 42

SP - 2639

EP - 2646

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 15

ER -

Overexpression of a member of the pentraxin family (PTX3) in human soft tissue liposarcoma

Abstract

Keywords

UN SDGs

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