Orotate complexes. Synthesis and crystal structure of lithium orotate(—I) monohydrate and magnesium bis[ orotate(—I)] octahydrate

Ina Bach, Otto Kumberger, Hubert Schmidbaur

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Neutralization of orotic acid (OrH2) by lithium or magnesium hydroxide in aqueous medium yields the crystalline metal orotate hydrates Li(OrH). H2O (1) and Mg(OrH)2. (H2O)6 (2). By single‐crystal X‐ray diffraction studies it has been shown that 1 (space group P1) forms a layer structure, with lithium in a tetrahedral environment of oxygen atoms from three different orotate( ‐ I) anions (one carboxylate and two uracil oxygen atoms) and the water molecule. 2 (space group P21/c) has been shown to feature a hexaquo complex of magnesium, the Mg(H2O)26 cations being associated with two hydrated OrH ions only through hydrogen bonds. The anions are also engaged in “base‐pairing” hydrogen bonds between the planar uracil ring systems of different units. The results are relevant for applications of magnesium orotates in magnesium therapy.

Original languageEnglish
Pages (from-to)2267-2271
Number of pages5
JournalChemische Berichte
Volume123
Issue number12
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • Lithium complexes
  • Magnesium complexes
  • Magnesium therapy
  • Orotate complexes, Salts

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