ORGANISCHE GRUNDLAGEN DEPRESSIVER SYMPTOME BEI DER ALZHEIMER DEMENZ. ERGEBNISSE EINER PROSPEKTIVEN UNTERSUCHUNG, LITERATURUBERSICHT

Translated title of the contribution: Neuropathological correlates of affective disturbances in Alzheimer's disease. A review and results of a prospective study

H. Forstl, A. Burns, N. Cairns, P. Luthert, P. Lantos, R. Levy

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The diagnosis of Alzheimer's disease (AD) was verified at post-mortem examination in 46 patients (9♂ : 37♀; mean age 83.6 ± 6.5 years) from a prospective clinical study. Compared to 10 age-matched controls, the total AD group showed a significant neuronal loss in the locus coeruleus, dorsal raphe nucleus, substantia nigra and in the basal nucleus of Meynert. Twelve patients (1♂ : 11♀) had experienced symptoms of depression. These patients had significantly lower neuronal counts in the locus coeruleus, but less severe cell loss in the basal nucleus of Meynert compared to the AD patients without depression.

Translated title of the contributionNeuropathological correlates of affective disturbances in Alzheimer's disease. A review and results of a prospective study
Original languageGerman
Pages (from-to)566-574
Number of pages9
JournalNervenarzt
Volume63
Issue number9
StatePublished - 1992
Externally publishedYes

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