Organisation und Erkenntnisse einer Pilotstudie zur allergologischen Abklärung einer COVID-19-Impfstoffallergie in der Weihnachtswoche 2021

Translated title of the contribution: Allergological clarification of suspected COVID-19 vaccine allergy in the Christmas week 2021: organization and findings of a pilot study

R. Bent, V. Faihs, U. Darsow, T. Biedermann, K. Brockow

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: In 2020 the COVID-19 pandemic spread due to the coronavirus SARS-CoV-2. Vaccination is crucial to fight the COVID-19 pandemic. Initial reports of anaphylaxis after vaccination caused concern and fear of the population and consequently a high demand for allergy testing. Methods: The need and reasons for allergy testing were recorded via questionnaires and the patients’ medical history. To study the possibility of higher-throughput allergy evaluation, additional new skin test appointment slots were created for patients concentrated during the Christmas week 2021 and the amount of material, time required, as well as the organization and the tolerability of subsequent vaccination were analyzed. Results: The demand for testing greatly exceeded the number of available standard appointment slots. Test indications were mostly the patients’ fear of an allergic reaction to the vaccine when a polyethylene glycol (PEG) allergy could not be unequivocally excluded in the patients’ history. Forty-one patients (38 females, 3 men, age 51 ± 17.7) were tested on 3 days. The average contact time needed per patients for the nurse was 30 minutes and for the physician 25 minutes. One patient could not be tested due to antihistamine use. After testing, in 36 cases routine vaccination was recommended; of those 35 patients got vaccinated. In four patients, an indication for inpatient PEG provocation or inpatient vaccination was given. Two thirds (27/41 patients, 65.9%) of all who were initially refusing vaccination got vaccinated shortly after allergy tests and tolerated this vaccination without major complications, an additional 9.8% intended future vaccination. Only four patients (9.8%) persistently refused vaccination after testing. Conclusions: In this pilot study, we show a useful and effective option to triage patients requesting COVID-19 vaccine allergy testing and generally how to process allergy appointments in a more time effective manner. Optimizing intraclinical processes leads to a substantially higher number of patients that can be allergy tested and vaccinated.

Translated title of the contributionAllergological clarification of suspected COVID-19 vaccine allergy in the Christmas week 2021: organization and findings of a pilot study
Original languageGerman
Pages (from-to)812-822
Number of pages11
JournalAllergologie
Volume45
Issue number11
DOIs
StatePublished - Nov 2022
Externally publishedYes

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