Organ changes after intravenous trinonanoin administration in rabbits

J. Linseisen; G. Wolfram

doi:10.1159/000177784

Organ changes after intravenous trinonanoin administration in rabbits

J. Linseisen
, G. Wolfram

Institut fur Ernahrungswissenschaft

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

For 11 days, an odd-numbered medium-chain triglyceride (trinonanoin, C₉TG)/long-chain triglyceride (LCT) emulsion was given parenterally to rabbits, providing 46.5% of total energy. In comparison with LCT or MCT/LCT fat emulsions, no negative effects on organ weights and liver lipid concentrations were noted. In some rabbits of the C₉TG/LCT group macroscopically but not histologically visible liver changes were observed. The extent of nonanoic acid deposition in liver triglycerides, liver phospholipids, adipose tissue and skeletal muscle after C₉TG/LCT administration was similar to C₈/C₁₀ deposition in the MCT/LCT group; the enrichment of adipose tissue with 16 mol% was higher than expected.

Original language	English
Pages (from-to)	328-334
Number of pages	7
Journal	Annals of Nutrition and Metabolism
Volume	37
Issue number	6
DOIs	https://doi.org/10.1159/000177784
State	Published - 1993
Externally published	Yes

Keywords

Liver histology
Organ fatty acids
Organ lipids
Organ masses
Parenteral nutrition
Rabbits
Trinonanoin

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10.1159/000177784

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title = "Organ changes after intravenous trinonanoin administration in rabbits",

abstract = "For 11 days, an odd-numbered medium-chain triglyceride (trinonanoin, C9TG)/long-chain triglyceride (LCT) emulsion was given parenterally to rabbits, providing 46.5\% of total energy. In comparison with LCT or MCT/LCT fat emulsions, no negative effects on organ weights and liver lipid concentrations were noted. In some rabbits of the C9TG/LCT group macroscopically but not histologically visible liver changes were observed. The extent of nonanoic acid deposition in liver triglycerides, liver phospholipids, adipose tissue and skeletal muscle after C9TG/LCT administration was similar to C8/C10 deposition in the MCT/LCT group; the enrichment of adipose tissue with 16 mol\% was higher than expected.",

keywords = "Liver histology, Organ fatty acids, Organ lipids, Organ masses, Parenteral nutrition, Rabbits, Trinonanoin",

author = "J. Linseisen and G. Wolfram",

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doi = "10.1159/000177784",

language = "English",

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journal = "Annals of Nutrition and Metabolism",

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TY - JOUR

T1 - Organ changes after intravenous trinonanoin administration in rabbits

AU - Linseisen, J.

AU - Wolfram, G.

PY - 1993

Y1 - 1993

N2 - For 11 days, an odd-numbered medium-chain triglyceride (trinonanoin, C9TG)/long-chain triglyceride (LCT) emulsion was given parenterally to rabbits, providing 46.5% of total energy. In comparison with LCT or MCT/LCT fat emulsions, no negative effects on organ weights and liver lipid concentrations were noted. In some rabbits of the C9TG/LCT group macroscopically but not histologically visible liver changes were observed. The extent of nonanoic acid deposition in liver triglycerides, liver phospholipids, adipose tissue and skeletal muscle after C9TG/LCT administration was similar to C8/C10 deposition in the MCT/LCT group; the enrichment of adipose tissue with 16 mol% was higher than expected.

AB - For 11 days, an odd-numbered medium-chain triglyceride (trinonanoin, C9TG)/long-chain triglyceride (LCT) emulsion was given parenterally to rabbits, providing 46.5% of total energy. In comparison with LCT or MCT/LCT fat emulsions, no negative effects on organ weights and liver lipid concentrations were noted. In some rabbits of the C9TG/LCT group macroscopically but not histologically visible liver changes were observed. The extent of nonanoic acid deposition in liver triglycerides, liver phospholipids, adipose tissue and skeletal muscle after C9TG/LCT administration was similar to C8/C10 deposition in the MCT/LCT group; the enrichment of adipose tissue with 16 mol% was higher than expected.

KW - Liver histology

KW - Organ fatty acids

KW - Organ lipids

KW - Organ masses

KW - Parenteral nutrition

KW - Rabbits

KW - Trinonanoin

UR - https://www.scopus.com/pages/publications/0027772704

U2 - 10.1159/000177784

DO - 10.1159/000177784

M3 - Article

C2 - 8109892

AN - SCOPUS:0027772704

SN - 0250-6807

VL - 37

SP - 328

EP - 334

JO - Annals of Nutrition and Metabolism

JF - Annals of Nutrition and Metabolism

IS - 6

ER -

Organ changes after intravenous trinonanoin administration in rabbits

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Keywords

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