Organ changes after intravenous trinonanoin administration in rabbits

J. Linseisen, G. Wolfram

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


For 11 days, an odd-numbered medium-chain triglyceride (trinonanoin, C9TG)/long-chain triglyceride (LCT) emulsion was given parenterally to rabbits, providing 46.5% of total energy. In comparison with LCT or MCT/LCT fat emulsions, no negative effects on organ weights and liver lipid concentrations were noted. In some rabbits of the C9TG/LCT group macroscopically but not histologically visible liver changes were observed. The extent of nonanoic acid deposition in liver triglycerides, liver phospholipids, adipose tissue and skeletal muscle after C9TG/LCT administration was similar to C8/C10 deposition in the MCT/LCT group; the enrichment of adipose tissue with 16 mol% was higher than expected.

Original languageEnglish
Pages (from-to)328-334
Number of pages7
JournalAnnals of Nutrition and Metabolism
Issue number6
StatePublished - 1993
Externally publishedYes


  • Liver histology
  • Organ fatty acids
  • Organ lipids
  • Organ masses
  • Parenteral nutrition
  • Rabbits
  • Trinonanoin


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