Orale Provokationstestung bei verzögerter Soforttypallergie auf Säugetierfleisch (Alpha-Gal)

Translated title of the contribution: Delayed anaphylaxis to mammalian meat (Alpha-Gal)-oral challenge

C. Kugler, T. Biedermann

Research output: Contribution to journalReview articlepeer-review

Abstract

Carbohydrate moieties are frequently encountered in food and can evoke IgE responses - The clinical signifcance of which, has been unclear, until recently. However, recent work has shown that IgE antibodies to galactose-alpha-1,3-galactose (AlphaGal), a carbohydrate commonly expressed on non-primate mammalian proteins, are capable of eliciting serious-even fatal-reactions. Sensitization may occur through tick bites. Upon exposure of sensitized subjects to mammalian red meat containing alpha-gal on glycoproteins, delayed anaphylaxis may ensue, often 3-6 hours after ingestion, in some cases in combination with trigger factors. In the following, the diagnostic workup for alpha-gal allergy is reviewed and discussed.

Translated title of the contributionDelayed anaphylaxis to mammalian meat (Alpha-Gal)-oral challenge
Original languageGerman
Pages (from-to)497-501
Number of pages5
JournalAllergologie
Volume39
Issue number11
DOIs
StatePublished - Nov 2016
Externally publishedYes

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