Abstract
Carbohydrate moieties are frequently encountered in food and can evoke IgE responses - The clinical signifcance of which, has been unclear, until recently. However, recent work has shown that IgE antibodies to galactose-alpha-1,3-galactose (AlphaGal), a carbohydrate commonly expressed on non-primate mammalian proteins, are capable of eliciting serious-even fatal-reactions. Sensitization may occur through tick bites. Upon exposure of sensitized subjects to mammalian red meat containing alpha-gal on glycoproteins, delayed anaphylaxis may ensue, often 3-6 hours after ingestion, in some cases in combination with trigger factors. In the following, the diagnostic workup for alpha-gal allergy is reviewed and discussed.
| Translated title of the contribution | Delayed anaphylaxis to mammalian meat (Alpha-Gal)-oral challenge |
|---|---|
| Original language | German |
| Pages (from-to) | 497-501 |
| Number of pages | 5 |
| Journal | Allergologie |
| Volume | 39 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2016 |