Oral squamous cell carcinoma: The impact of stage-dependent therapy regimes on postoperative disease recurrence

Tobias Unterhuber, Marcia Nona Duma, Andrea Rau, Markus Nieberler, Klaus Dietrich Wolff, Marco Rainer Kesting

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective To investigate disease recurrence among patients with oral squamous cell carcinoma (OSCC) and positive lymph node lesions receiving different therapy for different stages of the disease. Study Design One hundred sixty-one patients with biopsy-proven pN1 and pN2+ carcinomas were reviewed retrospectively. We investigated postoperative disease recurrence when using surgery alone (SA), adjuvant radiotherapy (RT), or adjuvant radiochemotherapy (RCT) and compared our results with the 2012 German guidelines. Results Among the study population, 60 (37%) experienced postoperative disease recurrence, 38% with SA, 42% with adjuvant RT, and 39% with adjuvant RCT (P =.420). In the case of pN1, the recurrence rate was 14% with SA, 32% with RT, and 33% with RCT (P =.156); and in pN2+, 60%, 49%, and 29%, respectively (P =.012). Conclusions Surgery plus adjuvant therapy has benefits with respect to postoperative disease recurrence in pN2+ OSCC. In pN1, surgery alone might be as effective as adjuvant RT or RCT.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume121
Issue number2
DOIs
StatePublished - 1 Feb 2016
Externally publishedYes

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