@inproceedings{d0bd7efe02444b3f8a42202ea1d7b07f,
title = "Optimization of light and sound delivery for in vivo whole-brain optoacoustic angiography of rodents",
abstract = "Cerebrovascular imaging of rodents is one of the trending applications of optoacoustics aimed at studying brain activity and pathology. Imaging of deep brain structures is often hindered by sub-optimal arrangement of the light delivery and acoustic detection systems. In our work we revisit the physics behind opto-acoustic signal generation and perform theoretical evaluation of optimal laser wavelengths with an aim of enabling whole brain cerebrovascular optoacoustic angiography in small rodents. A comprehensive model based on diffusion approximation was developed to simulate optoacoustic signal generation using optical and acoustic parameters closely mimicking a typical murine brain and surrounding tissues. The model revealed three characteristic wavelength ranges in the visible and near-infrared spectra optimally suited for imaging cerebral vasculature of different size and depth. The theoretical conclusions are confirmed by numerical simulations while in vivo imaging experiments further validated the capacity for accurately resolving brain vasculature at depths ranging between 0.7 and 7 mm.",
keywords = "cerebrovascular imaging, matrix array, optoacoustic angiography, ultrawideband ultrasonic detection",
author = "Pavel Subochev and Ekaterina Sergeeva and Mikhail Kirillin and Daria Kurakina and Anna Orlova and Alexey Kurnikov and De{\'a}n-Ben, {Xos{\'e} Lu{\'i}s} and Zhenyue Chen and Daniel Razansky",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Photons Plus Ultrasound: Imaging and Sensing 2021 ; Conference date: 06-03-2021 Through 11-03-2021",
year = "2021",
doi = "10.1117/12.2579210",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",
booktitle = "Photons Plus Ultrasound",
}