Optimal multiplicative control of bacterial quorum sensing under external enzyme impact

Anna Maslovskaya, Christina Kuttler, Alexander Chebotarev, Andrey Kovtanyuk

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5 Scopus citations

Abstract

The use of external enzymes provides an alternative way of reducing communication in pathogenic bacteria that may lead to the degradation of their signal and the loss of their pathogeneity. The present study considers an optimal control problem for the semilinear reaction-diffusion model of bacterial quorum sensing under the impact of external enzymes. Estimates of the solution of the controlled system are obtained, on the basis of which the solvability of the extremal problem is proved and the necessary optimality conditions of the first-order are derived. A numerical algorithm to find a solution of the optimal control problem is constructed and implemented. The conducted numerical experiments demonstrate an opportunity to build an effective strategy of the enzymes impact for treatment.

Original languageEnglish
Article number29
JournalMathematical Modelling of Natural Phenomena
Volume17
DOIs
StatePublished - 2022

Keywords

  • Bacterial quorum sensing
  • Optimal control problem
  • Optimality conditions
  • Semilinear parabolic equation
  • Signal degradation

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