Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis

Matthias H. Tschöp; Michael Stumvoll; Michael Ristow

doi:10.1016/j.cmet.2016.05.017

Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis

Matthias H. Tschöp, Michael Stumvoll, Michael Ristow

Medicine and Health

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

Type 2 diabetes is associated with increased risk of malignancies, whereas antidiabetic interventions like physical exercise or metformin reduce cancer incidence. A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels.

Original language	English
Pages (from-to)	959-960
Number of pages	2
Journal	Cell Metabolism
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2016.05.017
State	Published - 14 Jun 2016

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10.1016/j.cmet.2016.05.017

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title = "Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis",

abstract = "Type 2 diabetes is associated with increased risk of malignancies, whereas antidiabetic interventions like physical exercise or metformin reduce cancer incidence. A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels.",

author = "Tsch{\"o}p, {Matthias H.} and Michael Stumvoll and Michael Ristow",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

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doi = "10.1016/j.cmet.2016.05.017",

language = "English",

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AU - Tschöp, Matthias H.

AU - Stumvoll, Michael

AU - Ristow, Michael

PY - 2016/6/14

Y1 - 2016/6/14

N2 - Type 2 diabetes is associated with increased risk of malignancies, whereas antidiabetic interventions like physical exercise or metformin reduce cancer incidence. A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels.

AB - Type 2 diabetes is associated with increased risk of malignancies, whereas antidiabetic interventions like physical exercise or metformin reduce cancer incidence. A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels.

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U2 - 10.1016/j.cmet.2016.05.017

DO - 10.1016/j.cmet.2016.05.017

M3 - Short survey

C2 - 27304493

AN - SCOPUS:84975466423

SN - 1550-4131

VL - 23

SP - 959

EP - 960

JO - Cell Metabolism

JF - Cell Metabolism

IS - 6

ER -

Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis

Abstract

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