Opioidergic changes in the pineal gland and hypothalamus in cluster headache: A ligand PET study

T. Sprenger; F. Willoch; M. Miederer; F. Schindler; M. Valet; A. Berthele; M. E. Spilker; S. Förderreuther; A. Straube; I. Stangier; H. J. Wester; T. R. Tölle

doi:10.1212/01.wnl.0000204225.15947.f8

Opioidergic changes in the pineal gland and hypothalamus in cluster headache: A ligand PET study

T. Sprenger
, F. Willoch
, M. Miederer
, F. Schindler
, M. Valet
, A. Berthele
, M. E. Spilker
, S. Förderreuther
, A. Straube
, I. Stangier
, H. J. Wester
, T. R. Tölle

Technical University of Munich
Rikshospitalet-Radiumhospitalet HF
Ludwig-Maximilians-Universität München

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Using PET with the opioidergic ligand [C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the pathophysiology of cluster headache may relate to opioidergic dysfunction in circuitries generating the biologic clock.

Original language	English
Pages (from-to)	1108-1110
Number of pages	3
Journal	Neurology
Volume	66
Issue number	7
DOIs	https://doi.org/10.1212/01.wnl.0000204225.15947.f8
State	Published - Apr 2006

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title = "Opioidergic changes in the pineal gland and hypothalamus in cluster headache: A ligand PET study",

abstract = "Using PET with the opioidergic ligand [C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the pathophysiology of cluster headache may relate to opioidergic dysfunction in circuitries generating the biologic clock.",

author = "T. Sprenger and F. Willoch and M. Miederer and F. Schindler and M. Valet and A. Berthele and Spilker, \{M. E.\} and S. F{\"o}rderreuther and A. Straube and I. Stangier and Wester, \{H. J.\} and T{\"o}lle, \{T. R.\}",

note = "Funding Information: Supported by the Irmgard und Gerhard Schulz Fond, the SFB 391 C9, and a grant from the Deutsche Migr{\"a}ne und Kopfschmerzgesellschaft (DMKG). ",

year = "2006",

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doi = "10.1212/01.wnl.0000204225.15947.f8",

language = "English",

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T1 - Opioidergic changes in the pineal gland and hypothalamus in cluster headache

T2 - A ligand PET study

AU - Sprenger, T.

AU - Willoch, F.

AU - Miederer, M.

AU - Schindler, F.

AU - Valet, M.

AU - Berthele, A.

AU - Spilker, M. E.

AU - Förderreuther, S.

AU - Straube, A.

AU - Stangier, I.

AU - Wester, H. J.

AU - Tölle, T. R.

N1 - Funding Information: Supported by the Irmgard und Gerhard Schulz Fond, the SFB 391 C9, and a grant from the Deutsche Migräne und Kopfschmerzgesellschaft (DMKG).

PY - 2006/4

Y1 - 2006/4

N2 - Using PET with the opioidergic ligand [C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the pathophysiology of cluster headache may relate to opioidergic dysfunction in circuitries generating the biologic clock.

AB - Using PET with the opioidergic ligand [C]diprenorphine, the authors demonstrate decreased tracer binding in the pineal gland of cluster headache patients vs healthy volunteers. Opioid receptor availability in the hypothalamus and cingulate cortex depended on the duration of the headache disorder. Therefore, the pathophysiology of cluster headache may relate to opioidergic dysfunction in circuitries generating the biologic clock.

UR - https://www.scopus.com/pages/publications/33646109574

U2 - 10.1212/01.wnl.0000204225.15947.f8

DO - 10.1212/01.wnl.0000204225.15947.f8

M3 - Article

C2 - 16606930

AN - SCOPUS:33646109574

SN - 0028-3878

VL - 66

SP - 1108

EP - 1110

JO - Neurology

JF - Neurology

IS - 7

ER -

Opioidergic changes in the pineal gland and hypothalamus in cluster headache: A ligand PET study

Abstract

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