Ontogeny, differentiation and growth of the endocrine pancreas

Jochen Peters, Anja Jürgensen, Günter Klöppel

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

The pancreas develops from the primitive foregut endoderm, which differentiates into ductal, acinar and endocrine cells. This complex process is probably replicated in the adult pancreas when endocrine cell renewal is required, as may be the case in diabetes mellitus. This review describes what is known about the morphogenesis of the endocrine pancreas during ontogeny and the mechanisms regulating its differentiation and growth.

Original languageEnglish
Pages (from-to)527-538
Number of pages12
JournalVirchows Archiv
Volume436
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Differentiation
  • Endocrine pancreas
  • Growth
  • Morphogenesis

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