Onkologische Ursachen von Knochenschmerzen

Translated title of the contribution: Oncologic causes of bone pain

M. Nathrath, I. Teichert Von Lüttichau

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Bone pain is an important leading symptom and the most frequent single symptom of malignant disease in children and adolescents. For differential diagnosis, the character and localization of the pain are important. Of all malignant systemic hematologic disorders, acute leukemia accounts for the most cases of bone pain as a leading symptom. The pain mainly involves the long bones and is diffuse, intermittent, and migratory. In primary bone tumors such as osteosarcoma and Ewing's sarcoma, the pain usually starts intermittently, leading to a continuous pain of dull character, as the disease progresses. Solid tumors preferentially metastasizing into bone or bone marrow include rhabdomyosarcoma and neuroblastoma. Taking the rarity of malignant tumors into account, the clinician must maintain a high level of awareness regarding the association of bone pain with hematologic/oncologic disorders. Early diagnosis, however, is of crucial significance for the outcome of these diseases.

Translated title of the contributionOncologic causes of bone pain
Original languageGerman
Pages (from-to)655-660
Number of pages6
JournalMonatsschrift fur Kinderheilkunde
Issue number7
StatePublished - Jul 2009
Externally publishedYes


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