One hundred years after the discovery of insulin and glucagon: the history of tumors and hyperplasias that hypersecrete these hormones

Wouter W. de Herder, Günter Klöppel

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

One century ago, in 1922, Frederick G Banting, Charles H Best, James B Collip and John J R Macleod first published their experiments resulting in the isolation of a hypoglycemic factor, named insulin, from a solution extract from a dog’s pancreas. One year later, in 1923, a hyperglycemic factor named glucagon was isolated by Charles P Kimball and John R Murlin. In the following years, it could be demonstrated that pancreatic islet alpha- and beta-cell neoplasms and hyperplasias could inappropriately secrete excessive amounts of these two hormones. This review is a sequel to the discovery of insulin and glucagon and introduces the history of this fascinating group of neuroendocrine neoplasms and hyperplasias of the pancreas.

Original languageEnglish
Article numbere230046
Pages (from-to)RE
JournalEndocrine-Related Cancer
Volume30
Issue number9
DOIs
StatePublished - 2023

Keywords

  • congenital hyperinsulinism
  • glucagon
  • glucagonoma
  • glucagonomatosis
  • hypoglycemia
  • insulin
  • insulinoma
  • insulinomatosis
  • islets

Fingerprint

Dive into the research topics of 'One hundred years after the discovery of insulin and glucagon: the history of tumors and hyperplasias that hypersecrete these hormones'. Together they form a unique fingerprint.

Cite this