Oncogenic potential of hepatitis B virus encoded proteins

Marc Ringelhan; Ulrike Protzer

doi:10.1016/j.coviro.2015.08.015

Oncogenic potential of hepatitis B virus encoded proteins

Marc Ringelhan, Ulrike Protzer

Chair of Virology

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Due to the limited treatment options hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death, and hepatitis B virus (HBV) infection is the major risk factor for development of HCC worldwide. HCC is typically preceded by chronic inflammation, but may also develop in the absence of liver disease on the basis of HBV infection and even when virus replication is controlled by antivirals. In this situation, HBV antigen expression persists and direct oncogenic effects of HBV are integration of the viral DNA into the host genome as well as direct effects of viral proteins. These factors have to be taken into account in order to personalize HCC surveillance in CHB and unravel novel therapeutic approaches.

Original language	English
Pages (from-to)	109-115
Number of pages	7
Journal	Current Opinion in Virology
Volume	14
DOIs	https://doi.org/10.1016/j.coviro.2015.08.015
State	Published - 1 Oct 2015

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10.1016/j.coviro.2015.08.015

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title = "Oncogenic potential of hepatitis B virus encoded proteins",

abstract = "Due to the limited treatment options hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death, and hepatitis B virus (HBV) infection is the major risk factor for development of HCC worldwide. HCC is typically preceded by chronic inflammation, but may also develop in the absence of liver disease on the basis of HBV infection and even when virus replication is controlled by antivirals. In this situation, HBV antigen expression persists and direct oncogenic effects of HBV are integration of the viral DNA into the host genome as well as direct effects of viral proteins. These factors have to be taken into account in order to personalize HCC surveillance in CHB and unravel novel therapeutic approaches.",

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AU - Protzer, Ulrike

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N2 - Due to the limited treatment options hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death, and hepatitis B virus (HBV) infection is the major risk factor for development of HCC worldwide. HCC is typically preceded by chronic inflammation, but may also develop in the absence of liver disease on the basis of HBV infection and even when virus replication is controlled by antivirals. In this situation, HBV antigen expression persists and direct oncogenic effects of HBV are integration of the viral DNA into the host genome as well as direct effects of viral proteins. These factors have to be taken into account in order to personalize HCC surveillance in CHB and unravel novel therapeutic approaches.

AB - Due to the limited treatment options hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death, and hepatitis B virus (HBV) infection is the major risk factor for development of HCC worldwide. HCC is typically preceded by chronic inflammation, but may also develop in the absence of liver disease on the basis of HBV infection and even when virus replication is controlled by antivirals. In this situation, HBV antigen expression persists and direct oncogenic effects of HBV are integration of the viral DNA into the host genome as well as direct effects of viral proteins. These factors have to be taken into account in order to personalize HCC surveillance in CHB and unravel novel therapeutic approaches.

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DO - 10.1016/j.coviro.2015.08.015

M3 - Review article

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VL - 14

SP - 109

EP - 115

JO - Current Opinion in Virology

JF - Current Opinion in Virology

ER -

Oncogenic potential of hepatitis B virus encoded proteins

Abstract

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