Once Blind, Now We See GLP-1 Molecular Action

John P. Mayer; Matthias H. Tschöp; Richard D. DiMarchi

doi:10.1016/j.cmet.2017.07.014

Once Blind, Now We See GLP-1 Molecular Action

John P. Mayer, Matthias H. Tschöp, Richard D. DiMarchi

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

The macromolecular mechanics of GLP-1 with its cell surface receptor came into focus as two landmark publications recently published in Nature collectively herald advancement in structure-based design for a receptor class of great therapeutic importance (Jazayeri et al., 2017; Zhang et al., 2017).

Original language	English
Pages (from-to)	289-291
Number of pages	3
Journal	Cell Metabolism
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2017.07.014
State	Published - 1 Aug 2017
Externally published	Yes

Keywords

GLP-1
GPCR family B
cryoelectron microscopy
incretin
structure-based drug design

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10.1016/j.cmet.2017.07.014

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title = "Once Blind, Now We See GLP-1 Molecular Action",

abstract = "The macromolecular mechanics of GLP-1 with its cell surface receptor came into focus as two landmark publications recently published in Nature collectively herald advancement in structure-based design for a receptor class of great therapeutic importance (Jazayeri et al., 2017; Zhang et al., 2017).",

keywords = "GLP-1, GPCR family B, cryoelectron microscopy, incretin, structure-based drug design",

author = "Mayer, {John P.} and Tsch{\"o}p, {Matthias H.} and DiMarchi, {Richard D.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = aug,

day = "1",

doi = "10.1016/j.cmet.2017.07.014",

language = "English",

volume = "26",

pages = "289--291",

journal = "Cell Metabolism",

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publisher = "Cell Press",

number = "2",

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TY - JOUR

T1 - Once Blind, Now We See GLP-1 Molecular Action

AU - Mayer, John P.

AU - Tschöp, Matthias H.

AU - DiMarchi, Richard D.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - The macromolecular mechanics of GLP-1 with its cell surface receptor came into focus as two landmark publications recently published in Nature collectively herald advancement in structure-based design for a receptor class of great therapeutic importance (Jazayeri et al., 2017; Zhang et al., 2017).

AB - The macromolecular mechanics of GLP-1 with its cell surface receptor came into focus as two landmark publications recently published in Nature collectively herald advancement in structure-based design for a receptor class of great therapeutic importance (Jazayeri et al., 2017; Zhang et al., 2017).

KW - GLP-1

KW - GPCR family B

KW - cryoelectron microscopy

KW - incretin

KW - structure-based drug design

UR - http://www.scopus.com/inward/record.url?scp=85026223066&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2017.07.014

DO - 10.1016/j.cmet.2017.07.014

M3 - Short survey

C2 - 28768169

AN - SCOPUS:85026223066

SN - 1550-4131

VL - 26

SP - 289

EP - 291

JO - Cell Metabolism

JF - Cell Metabolism

IS - 2

ER -

Once Blind, Now We See GLP-1 Molecular Action

Abstract

Keywords

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