On quantification errors of R2* and proton density fat fraction mapping in trabecularized bone marrow in the static dephasing regime

Sophia Kronthaler, Maximilian N. Diefenbach, Christof Boehm, Mark Zamskiy, Marcus R. Makowski, Thomas Baum, Nico Sollmann, Dimitrios C. Karampinos

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To study the effect of field inhomogeneity distributions in trabecularized bone regions on the gradient echo (GRE) signal with short TEs and to characterize quantification errors on (Formula presented.) and proton density fat fraction (PDFF) maps when using a water-fat model with an exponential (Formula presented.) decay model at short TEs. Methods: Field distortions were simulated based on a trabecular bone micro CT dataset. Simulations were performed for different bone volume fractions (BV/TV) and for different bone-fat composition values. A multi-TE UTE acquisition was developed to acquire multiple UTEs with random order to minimize eddy currents. The acquisition was validated in phantoms and applied in vivo in a volunteer's ankle and knee. Chemical shift encoded MRI (CSE-MRI) based on a Cartesian multi-TE GRE scan was acquired in the spine of patients with metastatic bone disease. Results: Simulations showed that signal deviations from the exponential signal decay at short TEs were more prominent for a higher BV/TV. UTE multi-TE measurements reproduced in vivo the simulation-based predicted behavior. In regions with high BV/TV, the presence of field inhomogeneities induced an (Formula presented.) underestimation in trabecularized bone marrow when using CSE-MRI at 3T with a short TE. Conclusion: (Formula presented.) can be underestimated when using short TEs (<2 ms at 3 T) and a water-fat model with an exponential (Formula presented.) decay model in multi-echo GRE acquisitions of trabecularized bone marrow.

Original languageEnglish
Pages (from-to)1126-1139
Number of pages14
JournalMagnetic Resonance in Medicine
Volume88
Issue number3
DOIs
StatePublished - Sep 2022
Externally publishedYes

Keywords

  • Gaussian decay
  • PDFF mapping
  • R mapping
  • chemical shift encoding (CSE)
  • magnetically inhomogeneous tissues
  • signal decay
  • static dephasing regime
  • trabecularized bone
  • ultra-short echo time (UTE)

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