TY - JOUR
T1 - On-chip fast scan cyclic voltammetry for selective detection of redox active neurotransmitters
AU - Yakushenko, Alexey
AU - Schöps, Volker
AU - Mayer, Dirk
AU - Offenhäusser, Andreas
AU - Wolfrum, Bernhard
PY - 2014/6
Y1 - 2014/6
N2 - Fast scan cyclic voltammetry is a powerful technique for selective detection of biogenic amines in vivo and in vitro. Here we investigate this technique for multichannel spatiotemporal detection of neurotransmitter concentrations on a chip, using metal microelectrode arrays. The array-based approach allows monitoring concentration gradients of redox-active species at multiple highly localized (3 μm) positions simultaneously, while maintaining selectivity from the characteristic voltammogram shapes. We demonstrate that concentration fluctuations at individual electrode locations are resolved after spatially confined neurotransmitter injections. Furthermore, we discuss effects of microelectrode degradation caused by electrode sweeping during long-term experiments.
AB - Fast scan cyclic voltammetry is a powerful technique for selective detection of biogenic amines in vivo and in vitro. Here we investigate this technique for multichannel spatiotemporal detection of neurotransmitter concentrations on a chip, using metal microelectrode arrays. The array-based approach allows monitoring concentration gradients of redox-active species at multiple highly localized (3 μm) positions simultaneously, while maintaining selectivity from the characteristic voltammogram shapes. We demonstrate that concentration fluctuations at individual electrode locations are resolved after spatially confined neurotransmitter injections. Furthermore, we discuss effects of microelectrode degradation caused by electrode sweeping during long-term experiments.
KW - cyclic voltammetry
KW - microelectrode arrays
KW - neurotransmitters
UR - http://www.scopus.com/inward/record.url?scp=84902533568&partnerID=8YFLogxK
U2 - 10.1002/pssa.201330276
DO - 10.1002/pssa.201330276
M3 - Article
AN - SCOPUS:84902533568
SN - 1862-6300
VL - 211
SP - 1364
EP - 1371
JO - Physica Status Solidi (A) Applications and Materials Science
JF - Physica Status Solidi (A) Applications and Materials Science
IS - 6
ER -