Occurrence of SARS-CoV-2 in the intraocular milieu

Wolfgang List; Peter Regitnig; Karl Kashofer; Gregor Gorkiewicz; Martin Zacharias; Andreas Wedrich; Laura Posch-Pertl

doi:10.1016/j.exer.2020.108273

Occurrence of SARS-CoV-2 in the intraocular milieu

Wolfgang List
, Peter Regitnig
, Karl Kashofer
, Gregor Gorkiewicz
, Martin Zacharias
, Andreas Wedrich
, Laura Posch-Pertl

Medical University of Graz

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The purpose of this research is to study the intraocular occurrence of SARS-CoV-2. In postmortem examinations, aqueous humor and the vitreous samples were collected. All individuals were previously positive in nasopharyngeal swabbing and cause of death was respiratory failure due to SARS-CoV-2 infection. Testing was done using quantitative RT-PCR. We included 16 aqueous humor and 16 vitreous samples for PCR testing. None of the results was positive for SARS-CoV-2. Human GAPDH genes to verify the presence of RNA was present in all aqueous humor samples (16/16, 100%) and 15/16 (93.8%) vitreous samples. In conclusion, this case series found no evidence of SARS-CoV-2 in the intraocular milieu.

Original language	English
Article number	108273
Journal	Experimental Eye Research
Volume	201
DOIs	https://doi.org/10.1016/j.exer.2020.108273
State	Published - Dec 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aqueous humor
Intraocular milieu
SARS-CoV-2
Vitreous body

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10.1016/j.exer.2020.108273

Cite this

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title = "Occurrence of SARS-CoV-2 in the intraocular milieu",

abstract = "The purpose of this research is to study the intraocular occurrence of SARS-CoV-2. In postmortem examinations, aqueous humor and the vitreous samples were collected. All individuals were previously positive in nasopharyngeal swabbing and cause of death was respiratory failure due to SARS-CoV-2 infection. Testing was done using quantitative RT-PCR. We included 16 aqueous humor and 16 vitreous samples for PCR testing. None of the results was positive for SARS-CoV-2. Human GAPDH genes to verify the presence of RNA was present in all aqueous humor samples (16/16, 100\%) and 15/16 (93.8\%) vitreous samples. In conclusion, this case series found no evidence of SARS-CoV-2 in the intraocular milieu.",

keywords = "Aqueous humor, Intraocular milieu, SARS-CoV-2, Vitreous body",

author = "Wolfgang List and Peter Regitnig and Karl Kashofer and Gregor Gorkiewicz and Martin Zacharias and Andreas Wedrich and Laura Posch-Pertl",

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doi = "10.1016/j.exer.2020.108273",

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volume = "201",

journal = "Experimental Eye Research",

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}

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T1 - Occurrence of SARS-CoV-2 in the intraocular milieu

AU - List, Wolfgang

AU - Regitnig, Peter

AU - Kashofer, Karl

AU - Gorkiewicz, Gregor

AU - Zacharias, Martin

AU - Wedrich, Andreas

AU - Posch-Pertl, Laura

PY - 2020/12

Y1 - 2020/12

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AB - The purpose of this research is to study the intraocular occurrence of SARS-CoV-2. In postmortem examinations, aqueous humor and the vitreous samples were collected. All individuals were previously positive in nasopharyngeal swabbing and cause of death was respiratory failure due to SARS-CoV-2 infection. Testing was done using quantitative RT-PCR. We included 16 aqueous humor and 16 vitreous samples for PCR testing. None of the results was positive for SARS-CoV-2. Human GAPDH genes to verify the presence of RNA was present in all aqueous humor samples (16/16, 100%) and 15/16 (93.8%) vitreous samples. In conclusion, this case series found no evidence of SARS-CoV-2 in the intraocular milieu.

KW - Aqueous humor

KW - Intraocular milieu

KW - SARS-CoV-2

KW - Vitreous body

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DO - 10.1016/j.exer.2020.108273

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VL - 201

JO - Experimental Eye Research

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ER -

Occurrence of SARS-CoV-2 in the intraocular milieu

Abstract

UN SDGs

Keywords

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