Nutritive Auswirkungen einer intestinalen α-Glucosidasen-Hemmung bei Ratten

In a balance trial the effect of different dietary doses of the α-glucosidases-inhibitor Bay g 5421 on nutrient digestibility and N-balance was tested with rats. The supplements of 30, 90 and 210 mg Bay g 5421 per kg of feed reduced the digestibility of starch plus sucrose by 2, 16 and 27%. The protein digestibility decreased by 5, 14 and 19%. This shows that for the organism 3, 13 and 24% less digestible energy were available. The excretion of the urinary energy was not influenced in the different groups. The elevated fecal N excretion with the supplements of 30 and 90 mg Bay g 5421 per kg of feed was compensated by a lower N-excretion in the urine. At the dose level of 210 mg Bay g 5421 N balance was diminished.