Abstract
Based on the effects of a selective experimental zinc deficiency in a rodent model we explore the use of transcriptome profiling for assessing nutrient-gene interactions in the liver at the molecular and cellular levels. Zinc deficiency caused pleiotropic alterations in mRNA/protein levels of hundreds of genes. In the context of observed metabolic alterations in hepatic metabolism, possible mechanisms are discussed for how a low zinc status may be sensed and transmitted into changes in various metabolic pathways. However, it also becomes obvious that analysis of such complex nutrient-gene interactions beyond the descriptional level is a real challenge for systems biology.
| Original language | English |
|---|---|
| Pages (from-to) | 571-583 |
| Number of pages | 13 |
| Journal | Biological Chemistry |
| Volume | 385 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2004 |
Keywords
- Gene expression
- Liver
- Metabolism
- Nutrients
- Transcriptome analysis
- Zinc deficiency