Nutrient-gene interactions: A single nutrient and hundreds of target genes

Hannelore Daniel, Heike tom Dieck

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Based on the effects of a selective experimental zinc deficiency in a rodent model we explore the use of transcriptome profiling for assessing nutrient-gene interactions in the liver at the molecular and cellular levels. Zinc deficiency caused pleiotropic alterations in mRNA/protein levels of hundreds of genes. In the context of observed metabolic alterations in hepatic metabolism, possible mechanisms are discussed for how a low zinc status may be sensed and transmitted into changes in various metabolic pathways. However, it also becomes obvious that analysis of such complex nutrient-gene interactions beyond the descriptional level is a real challenge for systems biology.

Original languageEnglish
Pages (from-to)571-583
Number of pages13
JournalBiological Chemistry
Issue number7
StatePublished - Jul 2004


  • Gene expression
  • Liver
  • Metabolism
  • Nutrients
  • Transcriptome analysis
  • Zinc deficiency


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