Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus

Pierre Sonigo; Marc Alizon; Katherine Staskus; David Klatzmann; Stewart Cole; Olivier Danos; Ernest Retzel; Pierre Tiollais; Ashley Haase; Simon Wain-Hobson

doi:10.1016/S0092-8674(85)80132-X

Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus

Pierre Sonigo
, Marc Alizon
, Katherine Staskus
, David Klatzmann
, Stewart Cole
, Olivier Danos
, Ernest Retzel
, Pierre Tiollais
, Ashley Haase
, Simon Wain-Hobson

Research output: Contribution to journal › Article › peer-review

443 Scopus citations

Abstract

We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses. These findings support the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae.

Original language	English
Pages (from-to)	369-382
Number of pages	14
Journal	Cell
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/S0092-8674(85)80132-X
State	Published - Aug 1985
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/S0092-8674(85)80132-X

Cite this

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title = "Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus",

abstract = "We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses. These findings support the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae.",

author = "Pierre Sonigo and Marc Alizon and Katherine Staskus and David Klatzmann and Stewart Cole and Olivier Danos and Ernest Retzel and Pierre Tiollais and Ashley Haase and Simon Wain-Hobson",

year = "1985",

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T1 - Nucleotide sequence of the visna lentivirus

T2 - relationship to the AIDS virus

AU - Sonigo, Pierre

AU - Alizon, Marc

AU - Staskus, Katherine

AU - Klatzmann, David

AU - Cole, Stewart

AU - Danos, Olivier

AU - Retzel, Ernest

AU - Tiollais, Pierre

AU - Haase, Ashley

AU - Wain-Hobson, Simon

PY - 1985/8

Y1 - 1985/8

N2 - We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses. These findings support the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae.

AB - We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses. These findings support the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae.

UR - https://www.scopus.com/pages/publications/0022359843

U2 - 10.1016/S0092-8674(85)80132-X

DO - 10.1016/S0092-8674(85)80132-X

M3 - Article

C2 - 2410140

AN - SCOPUS:0022359843

SN - 0092-8674

VL - 42

SP - 369

EP - 382

JO - Cell

JF - Cell

IS - 1

ER -

Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus

Abstract

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