Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus

Pierre Sonigo, Marc Alizon, Katherine Staskus, David Klatzmann, Stewart Cole, Olivier Danos, Ernest Retzel, Pierre Tiollais, Ashley Haase, Simon Wain-Hobson

Research output: Contribution to journalArticlepeer-review

442 Scopus citations


We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses. These findings support the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae.

Original languageEnglish
Pages (from-to)369-382
Number of pages14
Issue number1
StatePublished - Aug 1985
Externally publishedYes


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