Abstract
(Chemical Equation Presented) Aminal pharm: Grignard reagents undergo a surprising nucleophilic aromatic addition reaction to cinchona alkaloids to stereoselectively produce cyclic aminals. Structurally diverse alkaloid derivatives with rigid cores that bear reactive functional groups (see examples) can be readily synthesized by this simple nucleophilic alkylation protocol.
| Original language | English |
|---|---|
| Pages (from-to) | 5164-5167 |
| Number of pages | 4 |
| Journal | Angewandte Chemie International Edition in English |
| Volume | 46 |
| Issue number | 27 |
| DOIs | |
| State | Published - 2007 |
| Externally published | Yes |
Keywords
- Cinchona alkaloids
- Grignard reaction
- Heterocycles
- Neighboring-group effects
- Nucleophilic addition
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