Nuclear receptors: TH17 cell control from within

L. Klotz; P. Knolle

doi:10.1016/j.febslet.2011.06.027

Nuclear receptors: T_H17 cell control from within

L. Klotz
, P. Knolle

University of Münster
Rheinische Friedrich-Wilhelms-Universität Bonn

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

IL-17 producing T helper (T_H17) cells have recently been identified as a new subset involved in the pathogenesis of various autoimmune diseases. Exogenous factors promoting T_H17 induction have been intensely characterized, whereas the T cell-intrinsic mechanisms influencing T_H17 development are less established. The transcription factor RORγt, which belongs to the nuclear receptor superfamily, serves as master transcription factor essential for T_H17 differentiation, whereas other members of the nuclear receptor family control T_H17 differentiation and contribute to protection from T_H17-mediated autoimmunity. In this review, we will highlight the most recent understandings about the regulatory function of nuclear receptors during T_H17 cell differentiation.

Original language	English
Pages (from-to)	3764-3769
Number of pages	6
Journal	FEBS Letters
Volume	585
Issue number	23
DOIs	https://doi.org/10.1016/j.febslet.2011.06.027
State	Published - 1 Dec 2011
Externally published	Yes

Keywords

Autoimmunity
Multiple sclerosis
Nuclear receptor
PPARγ
T17
Transrepression

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10.1016/j.febslet.2011.06.027

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title = "Nuclear receptors: TH17 cell control from within",

abstract = "IL-17 producing T helper (TH17) cells have recently been identified as a new subset involved in the pathogenesis of various autoimmune diseases. Exogenous factors promoting TH17 induction have been intensely characterized, whereas the T cell-intrinsic mechanisms influencing TH17 development are less established. The transcription factor RORγt, which belongs to the nuclear receptor superfamily, serves as master transcription factor essential for TH17 differentiation, whereas other members of the nuclear receptor family control TH17 differentiation and contribute to protection from TH17-mediated autoimmunity. In this review, we will highlight the most recent understandings about the regulatory function of nuclear receptors during TH17 cell differentiation.",

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T2 - TH17 cell control from within

AU - Klotz, L.

AU - Knolle, P.

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N2 - IL-17 producing T helper (TH17) cells have recently been identified as a new subset involved in the pathogenesis of various autoimmune diseases. Exogenous factors promoting TH17 induction have been intensely characterized, whereas the T cell-intrinsic mechanisms influencing TH17 development are less established. The transcription factor RORγt, which belongs to the nuclear receptor superfamily, serves as master transcription factor essential for TH17 differentiation, whereas other members of the nuclear receptor family control TH17 differentiation and contribute to protection from TH17-mediated autoimmunity. In this review, we will highlight the most recent understandings about the regulatory function of nuclear receptors during TH17 cell differentiation.

AB - IL-17 producing T helper (TH17) cells have recently been identified as a new subset involved in the pathogenesis of various autoimmune diseases. Exogenous factors promoting TH17 induction have been intensely characterized, whereas the T cell-intrinsic mechanisms influencing TH17 development are less established. The transcription factor RORγt, which belongs to the nuclear receptor superfamily, serves as master transcription factor essential for TH17 differentiation, whereas other members of the nuclear receptor family control TH17 differentiation and contribute to protection from TH17-mediated autoimmunity. In this review, we will highlight the most recent understandings about the regulatory function of nuclear receptors during TH17 cell differentiation.

KW - Autoimmunity

KW - Multiple sclerosis

KW - Nuclear receptor

KW - PPARγ

KW - T17

KW - Transrepression

UR - https://www.scopus.com/pages/publications/81755179403

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DO - 10.1016/j.febslet.2011.06.027

M3 - Review article

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AN - SCOPUS:81755179403

SN - 0014-5793

VL - 585

SP - 3764

EP - 3769

JO - FEBS Letters

JF - FEBS Letters

IS - 23

ER -

Nuclear receptors: T_H17 cell control from within

Abstract

Keywords

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