NRF2 signalling pathway: New insights and progress in the field of wound healing

Yang Liu, Xiaofan Yang, Yutian Liu, Tao Jiang, Sen Ren, Jing Chen, Hewei Xiong, Meng Yuan, Wenqing Li, Hans Günther Machens, Zhenbing Chen

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

As one of the most common pathological processes in the clinic, wound healing has always been an important topic in medical research. Improving the wound healing environment, shortening the healing time and promoting fast and effective wound healing are hot and challenging issues in clinical practice. The nuclear factor-erythroid–related factor 2 (NFE2L2 or NRF2) signalling pathway reduces oxidative damage and participates in the regulation of anti-oxidative gene expression in the process of oxidative stress and thus improves the cell protection. Activation of the NRF2 signalling pathway increases the resistance of the cell to chemical carcinogens and inflammation. The signal transduction pathway regulates anti-inflammatory and antioxidant effects by regulating calcium ions, mitochondrial oxidative stress, autophagy, ferroptosis, pyroptosis and apoptosis. In this article, the role of the NRF2 signalling pathway in wound healing and its research progress in recent years are reviewed. In short, the NRF2 signalling pathway has crucial clinical significance in wound healing and is worthy of further study.

Original languageEnglish
Pages (from-to)5857-5868
Number of pages12
JournalJournal of Cellular and Molecular Medicine
Volume25
Issue number13
DOIs
StatePublished - Jul 2021

Keywords

  • NRF2
  • ROS
  • oxidative stress
  • wound healing

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