Nonexponential ligand rebinding of CO and O2 in myoglobin controlled by fluctuations of the protein

A. A. Zharikov; Sighart F. Fischer

doi:10.1016/0009-2614(95)01450-0

Nonexponential ligand rebinding of CO and O₂ in myoglobin controlled by fluctuations of the protein

A. A. Zharikov
, Sighart F. Fischer

TUM Emeriti of Excellence

Technical University of Munich
Siberian Br. of Russ. Acad. of S.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The kinetics of first-order processes which depend on a fluctuating coordinate are studied analytically. The fluctuations are described as uncorrelated jumps with an arbitrary time distribution between jumps. As an example, the nonexponential ligand rebinding kinetics in proteins is analyzed in the adiabatic limit where the reaction is controlled by the motion along the reaction coordinate. A new powertime law is deduced for the rebinding at low temperatures.

Original language	English
Pages (from-to)	459-469
Number of pages	11
Journal	Chemical Physics Letters
Volume	249
Issue number	5-6
DOIs	https://doi.org/10.1016/0009-2614(95)01450-0
State	Published - 9 Feb 1996

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title = "Nonexponential ligand rebinding of CO and O2 in myoglobin controlled by fluctuations of the protein",

abstract = "The kinetics of first-order processes which depend on a fluctuating coordinate are studied analytically. The fluctuations are described as uncorrelated jumps with an arbitrary time distribution between jumps. As an example, the nonexponential ligand rebinding kinetics in proteins is analyzed in the adiabatic limit where the reaction is controlled by the motion along the reaction coordinate. A new powertime law is deduced for the rebinding at low temperatures.",

author = "Zharikov, \{A. A.\} and Fischer, \{Sighart F.\}",

note = "Funding Information: The authors are grateful to Professor F. Parak for stimulating discussions. This work was supported by the Deutsche Forschungsgemeinschaft (SFB 143 SFB 377).",

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T1 - Nonexponential ligand rebinding of CO and O2 in myoglobin controlled by fluctuations of the protein

AU - Zharikov, A. A.

AU - Fischer, Sighart F.

N1 - Funding Information: The authors are grateful to Professor F. Parak for stimulating discussions. This work was supported by the Deutsche Forschungsgemeinschaft (SFB 143 SFB 377).

PY - 1996/2/9

Y1 - 1996/2/9

N2 - The kinetics of first-order processes which depend on a fluctuating coordinate are studied analytically. The fluctuations are described as uncorrelated jumps with an arbitrary time distribution between jumps. As an example, the nonexponential ligand rebinding kinetics in proteins is analyzed in the adiabatic limit where the reaction is controlled by the motion along the reaction coordinate. A new powertime law is deduced for the rebinding at low temperatures.

AB - The kinetics of first-order processes which depend on a fluctuating coordinate are studied analytically. The fluctuations are described as uncorrelated jumps with an arbitrary time distribution between jumps. As an example, the nonexponential ligand rebinding kinetics in proteins is analyzed in the adiabatic limit where the reaction is controlled by the motion along the reaction coordinate. A new powertime law is deduced for the rebinding at low temperatures.

UR - https://www.scopus.com/pages/publications/0030576017

U2 - 10.1016/0009-2614(95)01450-0

DO - 10.1016/0009-2614(95)01450-0

M3 - Article

AN - SCOPUS:0030576017

SN - 0009-2614

VL - 249

SP - 459

EP - 469

JO - Chemical Physics Letters

JF - Chemical Physics Letters

IS - 5-6

ER -

Nonexponential ligand rebinding of CO and O₂ in myoglobin controlled by fluctuations of the protein

Abstract

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