Non-invasive in-vivo sensing of metabolites with a novel optoacoustic spectroscope in the SWIR

M. Mehdi Seyedebrahimi; Miguel A. Pleitez; Pouyan Mohajerani; Vasilis Ntziachristos

doi:10.1117/12.2531625

Non-invasive in-vivo sensing of metabolites with a novel optoacoustic spectroscope in the SWIR

M. Mehdi Seyedebrahimi, Miguel A. Pleitez, Pouyan Mohajerani, Vasilis Ntziachristos

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this work we developed a novel near-infrared two-path optoacoustic spectrometer (NiR-TAOS) that could sense OA intensity changes due to metabolite concentration changes in-vivo. The main aim of dividing the optical path in two is 1) perform real time correction of the laser emission profile of the laser source at different wavelengths and, 2) perform pulse to pulse correction to remove laser beam fluctuation and instability to increase signal to noise ratio. Signal to noise ratio improvement was significant not only at spectral peaks, but also at all other wavelengths. The system can be used for broad applications in biomedical measurements such as various metabolites in the SWIR.

Original language	English
Title of host publication	Opto-Acoustic Methods and Applications in Biophotonics IV
Editors	Vasilis Ntziachristos, Roger Zemp
Publisher	SPIE
ISBN (Electronic)	9781510628472
DOIs	https://doi.org/10.1117/12.2531625
State	Published - 2019
Event	Opto-Acoustic Methods and Applications in Biophotonics IV 2019 - Munich, Germany Duration: 24 Jun 2019 → 25 Jun 2019

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11077
ISSN (Print)	1605-7422

Conference

Conference	Opto-Acoustic Methods and Applications in Biophotonics IV 2019
Country/Territory	Germany
City	Munich
Period	24/06/19 → 25/06/19

Keywords

Nearinfrared two-path OAS
Non-invasive In-vivo sensing of metabolites
Optoacoustic
Sensitivity and specificity improvement

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10.1117/12.2531625

Cite this

Seyedebrahimi, M. M., Pleitez, M. A., Mohajerani, P., & Ntziachristos, V. (2019). Non-invasive in-vivo sensing of metabolites with a novel optoacoustic spectroscope in the SWIR. In V. Ntziachristos, & R. Zemp (Eds.), Opto-Acoustic Methods and Applications in Biophotonics IV Article 110771H (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11077). SPIE. https://doi.org/10.1117/12.2531625

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title = "Non-invasive in-vivo sensing of metabolites with a novel optoacoustic spectroscope in the SWIR",

abstract = "In this work we developed a novel near-infrared two-path optoacoustic spectrometer (NiR-TAOS) that could sense OA intensity changes due to metabolite concentration changes in-vivo. The main aim of dividing the optical path in two is 1) perform real time correction of the laser emission profile of the laser source at different wavelengths and, 2) perform pulse to pulse correction to remove laser beam fluctuation and instability to increase signal to noise ratio. Signal to noise ratio improvement was significant not only at spectral peaks, but also at all other wavelengths. The system can be used for broad applications in biomedical measurements such as various metabolites in the SWIR.",

keywords = "Nearinfrared two-path OAS, Non-invasive In-vivo sensing of metabolites, Optoacoustic, Sensitivity and specificity improvement",

author = "Seyedebrahimi, {M. Mehdi} and Pleitez, {Miguel A.} and Pouyan Mohajerani and Vasilis Ntziachristos",

note = "Publisher Copyright: {\textcopyright} 2019 SPIE-OSA.; Opto-Acoustic Methods and Applications in Biophotonics IV 2019 ; Conference date: 24-06-2019 Through 25-06-2019",

year = "2019",

doi = "10.1117/12.2531625",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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editor = "Vasilis Ntziachristos and Roger Zemp",

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Seyedebrahimi, MM, Pleitez, MA, Mohajerani, P & Ntziachristos, V 2019, Non-invasive in-vivo sensing of metabolites with a novel optoacoustic spectroscope in the SWIR. in V Ntziachristos & R Zemp (eds), Opto-Acoustic Methods and Applications in Biophotonics IV., 110771H, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11077, SPIE, Opto-Acoustic Methods and Applications in Biophotonics IV 2019, Munich, Germany, 24/06/19. https://doi.org/10.1117/12.2531625

Non-invasive in-vivo sensing of metabolites with a novel optoacoustic spectroscope in the SWIR. / Seyedebrahimi, M. Mehdi; Pleitez, Miguel A.; Mohajerani, Pouyan et al.
Opto-Acoustic Methods and Applications in Biophotonics IV. ed. / Vasilis Ntziachristos; Roger Zemp. SPIE, 2019. 110771H (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11077).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - In this work we developed a novel near-infrared two-path optoacoustic spectrometer (NiR-TAOS) that could sense OA intensity changes due to metabolite concentration changes in-vivo. The main aim of dividing the optical path in two is 1) perform real time correction of the laser emission profile of the laser source at different wavelengths and, 2) perform pulse to pulse correction to remove laser beam fluctuation and instability to increase signal to noise ratio. Signal to noise ratio improvement was significant not only at spectral peaks, but also at all other wavelengths. The system can be used for broad applications in biomedical measurements such as various metabolites in the SWIR.

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Non-invasive in-vivo sensing of metabolites with a novel optoacoustic spectroscope in the SWIR

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