Non-invasive In-vivo sensing of metabolites with a novel Optoacoustic Spectroscope in the SWIR

M. Mehdi Seyedebrahimi; Miguel A. Pleitez; Pouyan Mohajerani; Vasilis Ntziachristos

doi:10.1117/12.2531625

Non-invasive In-vivo sensing of metabolites with a novel Optoacoustic Spectroscope in the SWIR

M. Mehdi Seyedebrahimi, Miguel A. Pleitez, Pouyan Mohajerani, Vasilis Ntziachristos

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this work we developed a novel near-infrared two-path optoacoustic spectrometer (NiR-TAOS) that could sense OA intensity changes due to metabolite concentration changes in-vivo. The main aim of dividing the optical path in two is 1) perform real time correction of the laser emission profile of the laser source at different wavelengths and, 2) perform pulse to pulse correction to remove laser beam fluctuation and instability to increase signal to noise ratio. Signal to noise ratio improvement was significant not only at spectral peaks, but also at all other wavelengths. The system can be used for broad applications in biomedical measurements such as various metabolites in the SWIR.

Original language	English
Title of host publication	European Conference on Biomedical Optics, ECBO_2019
Publisher	Optica Publishing Group (formerly OSA)
ISBN (Print)	9781510628397
DOIs	https://doi.org/10.1117/12.2531625
State	Published - 2019
Event	European Conference on Biomedical Optics, ECBO_2019 - Munich, Netherlands Duration: 23 Jun 2019 → 25 Jun 2019

Publication series

Name	Optics InfoBase Conference Papers
Volume	Part F142-ECBO 2019
ISSN (Electronic)	2162-2701

Conference

Conference	European Conference on Biomedical Optics, ECBO_2019
Country/Territory	Netherlands
City	Munich
Period	23/06/19 → 25/06/19

Keywords

Near-infrared two-path OAS
Non-invasive In-vivo sensing of metabolites
Optoacoustic
Sensitivity and specificity improvement

Access to Document

10.1117/12.2531625

Cite this

Seyedebrahimi, M. M., Pleitez, M. A., Mohajerani, P., & Ntziachristos, V. (2019). Non-invasive In-vivo sensing of metabolites with a novel Optoacoustic Spectroscope in the SWIR. In European Conference on Biomedical Optics, ECBO_2019 (Optics InfoBase Conference Papers; Vol. Part F142-ECBO 2019). Optica Publishing Group (formerly OSA). https://doi.org/10.1117/12.2531625

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title = "Non-invasive In-vivo sensing of metabolites with a novel Optoacoustic Spectroscope in the SWIR",

abstract = "In this work we developed a novel near-infrared two-path optoacoustic spectrometer (NiR-TAOS) that could sense OA intensity changes due to metabolite concentration changes in-vivo. The main aim of dividing the optical path in two is 1) perform real time correction of the laser emission profile of the laser source at different wavelengths and, 2) perform pulse to pulse correction to remove laser beam fluctuation and instability to increase signal to noise ratio. Signal to noise ratio improvement was significant not only at spectral peaks, but also at all other wavelengths. The system can be used for broad applications in biomedical measurements such as various metabolites in the SWIR.",

keywords = "Near-infrared two-path OAS, Non-invasive In-vivo sensing of metabolites, Optoacoustic, Sensitivity and specificity improvement",

author = "Seyedebrahimi, {M. Mehdi} and Pleitez, {Miguel A.} and Pouyan Mohajerani and Vasilis Ntziachristos",

note = "Publisher Copyright: {\textcopyright} SPIE-OSA 2019.; European Conference on Biomedical Optics, ECBO_2019 ; Conference date: 23-06-2019 Through 25-06-2019",

year = "2019",

doi = "10.1117/12.2531625",

language = "English",

isbn = "9781510628397",

series = "Optics InfoBase Conference Papers",

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Seyedebrahimi, MM, Pleitez, MA, Mohajerani, P & Ntziachristos, V 2019, Non-invasive In-vivo sensing of metabolites with a novel Optoacoustic Spectroscope in the SWIR. in European Conference on Biomedical Optics, ECBO_2019. Optics InfoBase Conference Papers, vol. Part F142-ECBO 2019, Optica Publishing Group (formerly OSA), European Conference on Biomedical Optics, ECBO_2019, Munich, Netherlands, 23/06/19. https://doi.org/10.1117/12.2531625

Non-invasive In-vivo sensing of metabolites with a novel Optoacoustic Spectroscope in the SWIR. / Seyedebrahimi, M. Mehdi; Pleitez, Miguel A.; Mohajerani, Pouyan et al.
European Conference on Biomedical Optics, ECBO_2019. Optica Publishing Group (formerly OSA), 2019. (Optics InfoBase Conference Papers; Vol. Part F142-ECBO 2019).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Ntziachristos, Vasilis

N1 - Publisher Copyright: © SPIE-OSA 2019.

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N2 - In this work we developed a novel near-infrared two-path optoacoustic spectrometer (NiR-TAOS) that could sense OA intensity changes due to metabolite concentration changes in-vivo. The main aim of dividing the optical path in two is 1) perform real time correction of the laser emission profile of the laser source at different wavelengths and, 2) perform pulse to pulse correction to remove laser beam fluctuation and instability to increase signal to noise ratio. Signal to noise ratio improvement was significant not only at spectral peaks, but also at all other wavelengths. The system can be used for broad applications in biomedical measurements such as various metabolites in the SWIR.

AB - In this work we developed a novel near-infrared two-path optoacoustic spectrometer (NiR-TAOS) that could sense OA intensity changes due to metabolite concentration changes in-vivo. The main aim of dividing the optical path in two is 1) perform real time correction of the laser emission profile of the laser source at different wavelengths and, 2) perform pulse to pulse correction to remove laser beam fluctuation and instability to increase signal to noise ratio. Signal to noise ratio improvement was significant not only at spectral peaks, but also at all other wavelengths. The system can be used for broad applications in biomedical measurements such as various metabolites in the SWIR.

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Non-invasive In-vivo sensing of metabolites with a novel Optoacoustic Spectroscope in the SWIR

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