TY - JOUR
T1 - Non-diabetic chronic kidney disease influences retinal microvasculature
AU - Baumann, Marcus
AU - Schwarz, Sonja
AU - Kotliar, Konstantin
AU - Von Eynatten, Maximilian
AU - Schmidt Trucksaess, Arno
AU - Burkhardt, Klaus
AU - Lutz, Jens
AU - Heemann, Uwe
AU - Lanzl, Ines
PY - 2010/1
Y1 - 2010/1
N2 - Background: Chronic kidney disease (CKD) is characterized by increased cerebrovascular risk. Retinal vessel analysis (RVA) is an accepted measure of the retinal microvasculature, mirrors hypertension and cardiovascular morbidity. Epidemiological studies demonstrate narrower retinal arterioles with declining renal function. The effect of CKD on the retinal microcirculation remains uncertain. Methods: RVA was performed in 34 non-diabetic CKD patients and 33 age-matched volunteers with normal renal function. Retinal photographs were digitized, vascular lumen diameters measured and the ratio of retinal arteriolar and venular lumen diameters (AVR) calculated. Office blood pressure (BP) was measured and cardiovascular risk factors assessed. Results: AVR was lower in CKD patients as compared to age-matched volunteers (0.77 ± 0.05 vs. 0.86 ± 0.06; p < 0.05). In particular, retinal arterioles were narrower in CKD patients as compared to volunteers (169.6 ± 20.4 vs. 189.5 ± 14.2 μm; p < 0.01). In CKD, estimated glomerular filtration rate, BP and renin-angiotensin system blocker independently predicted AVR. Moreover, retinal arteriolar diameter independently predicted renal function (β = 0.33; p < 0.05). Conclusion: CKD narrowed retinal arterioles suggesting an extended effect of CKD on the cerebral microvasculature. This study shows that in CKD patients, renal function, BP status and renin-angiotensin system blockade independently predict AVR as a marker for microvascular damage and that retinal microvasculature can predict renal function.
AB - Background: Chronic kidney disease (CKD) is characterized by increased cerebrovascular risk. Retinal vessel analysis (RVA) is an accepted measure of the retinal microvasculature, mirrors hypertension and cardiovascular morbidity. Epidemiological studies demonstrate narrower retinal arterioles with declining renal function. The effect of CKD on the retinal microcirculation remains uncertain. Methods: RVA was performed in 34 non-diabetic CKD patients and 33 age-matched volunteers with normal renal function. Retinal photographs were digitized, vascular lumen diameters measured and the ratio of retinal arteriolar and venular lumen diameters (AVR) calculated. Office blood pressure (BP) was measured and cardiovascular risk factors assessed. Results: AVR was lower in CKD patients as compared to age-matched volunteers (0.77 ± 0.05 vs. 0.86 ± 0.06; p < 0.05). In particular, retinal arterioles were narrower in CKD patients as compared to volunteers (169.6 ± 20.4 vs. 189.5 ± 14.2 μm; p < 0.01). In CKD, estimated glomerular filtration rate, BP and renin-angiotensin system blocker independently predicted AVR. Moreover, retinal arteriolar diameter independently predicted renal function (β = 0.33; p < 0.05). Conclusion: CKD narrowed retinal arterioles suggesting an extended effect of CKD on the cerebral microvasculature. This study shows that in CKD patients, renal function, BP status and renin-angiotensin system blockade independently predict AVR as a marker for microvascular damage and that retinal microvasculature can predict renal function.
KW - Arteriolar narrowing
KW - Arteriolar-venular ratio
KW - Chronic kidney disease
KW - Retinal vessel analysis
UR - http://www.scopus.com/inward/record.url?scp=71249128711&partnerID=8YFLogxK
U2 - 10.1159/000264650
DO - 10.1159/000264650
M3 - Article
C2 - 19996611
AN - SCOPUS:71249128711
SN - 1420-4096
VL - 32
SP - 428
EP - 433
JO - Kidney and Blood Pressure Research
JF - Kidney and Blood Pressure Research
IS - 6
ER -