Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses

Heli Venhoranta; Shun Li; Sylwia Salamon; Tatiana Flisikowska; Magnus Andersson; Marek Switonski; Alexander Kind; Angelika Schnieke; Krzysztof Flisikowski

doi:10.1016/j.bbrc.2014.01.071

Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses

Heli Venhoranta
, Shun Li
, Sylwia Salamon
, Tatiana Flisikowska
, Magnus Andersson
, Marek Switonski
, Alexander Kind
, Angelika Schnieke
, Krzysztof Flisikowski

TUM Emeriti of Excellence

University of Helsinki
Technical University of Munich
Poznan University of Life Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The existence of non-CpG methylation in mammalian DNA has mainly been observed in embryonic stem cells, but its functional significance is uncertain. We found an age-dependent non-CpG hypermethylation in DMR at the 3′ end of the MIMT1 in the placenta of intrauterine growth restricted foetuses in cattle. Data suggest that this DMR play a role in epigenetic regulation of the PEG3 domain.

Original language	English
Pages (from-to)	391-394
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	444
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2014.01.071
State	Published - 14 Feb 2014

Keywords

Epigenetic regulation
Intrauterine growth restriction
Mammalian DNA
Non-CpG methylation
PEG3

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10.1016/j.bbrc.2014.01.071

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title = "Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses",

abstract = "The existence of non-CpG methylation in mammalian DNA has mainly been observed in embryonic stem cells, but its functional significance is uncertain. We found an age-dependent non-CpG hypermethylation in DMR at the 3′ end of the MIMT1 in the placenta of intrauterine growth restricted foetuses in cattle. Data suggest that this DMR play a role in epigenetic regulation of the PEG3 domain.",

keywords = "Epigenetic regulation, Intrauterine growth restriction, Mammalian DNA, Non-CpG methylation, PEG3",

author = "Heli Venhoranta and Shun Li and Sylwia Salamon and Tatiana Flisikowska and Magnus Andersson and Marek Switonski and Alexander Kind and Angelika Schnieke and Krzysztof Flisikowski",

note = "Funding Information: This work was partially supported by National Science Centre of Poland , Grant No. DEC- 2013/09/B/NZ9/03160 .",

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T1 - Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses

AU - Venhoranta, Heli

AU - Li, Shun

AU - Salamon, Sylwia

AU - Flisikowska, Tatiana

AU - Andersson, Magnus

AU - Switonski, Marek

AU - Kind, Alexander

AU - Schnieke, Angelika

AU - Flisikowski, Krzysztof

N1 - Funding Information: This work was partially supported by National Science Centre of Poland , Grant No. DEC- 2013/09/B/NZ9/03160 .

PY - 2014/2/14

Y1 - 2014/2/14

N2 - The existence of non-CpG methylation in mammalian DNA has mainly been observed in embryonic stem cells, but its functional significance is uncertain. We found an age-dependent non-CpG hypermethylation in DMR at the 3′ end of the MIMT1 in the placenta of intrauterine growth restricted foetuses in cattle. Data suggest that this DMR play a role in epigenetic regulation of the PEG3 domain.

AB - The existence of non-CpG methylation in mammalian DNA has mainly been observed in embryonic stem cells, but its functional significance is uncertain. We found an age-dependent non-CpG hypermethylation in DMR at the 3′ end of the MIMT1 in the placenta of intrauterine growth restricted foetuses in cattle. Data suggest that this DMR play a role in epigenetic regulation of the PEG3 domain.

KW - Epigenetic regulation

KW - Intrauterine growth restriction

KW - Mammalian DNA

KW - Non-CpG methylation

KW - PEG3

UR - https://www.scopus.com/pages/publications/84894187010

U2 - 10.1016/j.bbrc.2014.01.071

DO - 10.1016/j.bbrc.2014.01.071

M3 - Article

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AN - SCOPUS:84894187010

SN - 0006-291X

VL - 444

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EP - 394

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses

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Keywords

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