TY - JOUR
T1 - NOESY‐TOCSY, an Advantageous 2D NMR Technique for the Analysis of Peptide Sequences
AU - Kessler, Horst
AU - Gemmecker, Gerd
AU - Steuernagel, Stefan
PY - 1988/4
Y1 - 1988/4
N2 - Molecules that exhibit strong negative NOEs and line broadening in the NMR spectrum due to short relaxation times are particularly good objects of investigations using the variants of unsymmetric 2D NMR techniques discussed here. Undesired signals can be suppressed by data processing, thus allowing, for example, the amino acid sequence of a peptide or protein to be easily determined. The nonsymmetry results from the fact that, across the peptide bond, NOE but no scalar coupling of protons is observed. (Figure Presented.)
AB - Molecules that exhibit strong negative NOEs and line broadening in the NMR spectrum due to short relaxation times are particularly good objects of investigations using the variants of unsymmetric 2D NMR techniques discussed here. Undesired signals can be suppressed by data processing, thus allowing, for example, the amino acid sequence of a peptide or protein to be easily determined. The nonsymmetry results from the fact that, across the peptide bond, NOE but no scalar coupling of protons is observed. (Figure Presented.)
UR - http://www.scopus.com/inward/record.url?scp=84990106362&partnerID=8YFLogxK
U2 - 10.1002/anie.198805641
DO - 10.1002/anie.198805641
M3 - Article
AN - SCOPUS:84990106362
SN - 0570-0833
VL - 27
SP - 564
EP - 566
JO - Angewandte Chemie International Edition in English
JF - Angewandte Chemie International Edition in English
IS - 4
ER -