NOESY‐TOCSY, an Advantageous 2D NMR Technique for the Analysis of Peptide Sequences

Horst Kessler, Gerd Gemmecker, Stefan Steuernagel

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Molecules that exhibit strong negative NOEs and line broadening in the NMR spectrum due to short relaxation times are particularly good objects of investigations using the variants of unsymmetric 2D NMR techniques discussed here. Undesired signals can be suppressed by data processing, thus allowing, for example, the amino acid sequence of a peptide or protein to be easily determined. The nonsymmetry results from the fact that, across the peptide bond, NOE but no scalar coupling of protons is observed. (Figure Presented.)

Original languageEnglish
Pages (from-to)564-566
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume27
Issue number4
DOIs
StatePublished - Apr 1988
Externally publishedYes

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